Mac OS X 10.4: Significant slow-down? Check Activity Monitor
Users experiencing unusually slow overall system performance after upgrading to Mac OS X 10.4 (Tiger) should use Activity Monitor (located in Applications/Utilities) to check for problematic third-party system utilities and other components that, for one reason or another, consume large amounts of resources under Mac OS X 10.4.
MacFixIt reader Jeff LaSorella reports a case example involving the utility "iSeek."
Jeff writes:
"After installing Tiger, I noticed a significant loss of speed on my computer in just about every program. After speaking with an Apple sales assistant at my local Apple store, he mentioned to check the Activity Monitor application to see if I could determine what was going on. I opened it and noticed the Iseek application I had installed a long time ago was sucking up 66% of my processor. As soon as I quit it and restarted, my processor speed came right back."
Resources

Amnesty, a free applications that puts your wickets into a menu was consuming
60% of my CPU and I had 0% idle. On closing Amnesty my idle CPU now varies
between 40 and 72%
Stan Kegel