Not that mousing is all that painful with the Microsoft Natural Ergonomic Desktop 7000. In fact, though wrist pain forced us to start mousing with our left hand years ago, we found ourselves eschewing our own Logitech MX610 left-handed mouse in favor of the right-handed Microsoft Natural Ergonomic mouse. (Though we'd still prefer to have a left-handed version, which Microsoft sadly lacks.)
The elevated mouse looks more like a piece of fruit than a computer accessory, and its buttons, wheel, and palm rest all veer toward the right side. The idea behind the design is that it turns your wrist upward (almost, though not quite, like a handshake) and lets you rest your hand on the right side instead of putting pressure on the carpal tunnel area. The thumb rest and sides of the mouse are made of a rubberized material that lets users avoid the mouse death grip that so often accompanies extended computer work.
As with the keyboard, our primary complaint relates to resistance: In this case, the rubberized scroll wheel offers a bit more drag than we'd prefer. Also, though the mouse does incorporate thumb buttons, their poor placement between the thumb and forefinger meant that we hardly used them--they were just too difficult to reach without moving our entire hand.
Microsoft offers a three-year warranty on the Natural Ergonomic Desktop 7000. Phone support is free for the first 90 days--after that, support will cost $35 per request. The company's support Web site has a searchable knowledge base, FAQs, and software updates. You can also access chat and e-mail support at the site.