| Unlockables |
|
| Action | Result |
| Beat the game | Movie Browser |
| Beat the main game once | Professional Difficulty |
| Beat the main game once | Seperate Ways (Ada's Bonus Game) |
| Beat the main game once | Mercenaries |
| Beat the main game | Special clothes for Leon, Ada, and Ashley |
| Beat the game once | Matilda |
| Have each mercenary get a five star rating on all of the stages | Handcannon |
| Beat the game once | Infinite Rocket Launcher |
| Beat Seperate Ways | Leon's gangster outfit |
| Beat Seperate Ways | Ashley's knight armor outfit |
| Complete the main game once. | Alternate Title Screen |
| Beat Seperate Ways | Chicago Typewriter (Main Game) |
| Beat Assignment Ada | Chicago Typewriter (Seperate Ways) |
| Beat Professional Mode | P.R.L 412 |
| Beat seperate ways once | Seperate ways movie browser |
| Bottle Caps |
| After you enter the Castle, and go through the Hall of Water to the Observation Hall. Next to the Merchant, A blue door with golden gun engravements lies in wait. Go through the door and begin the Target Practice game. Select Game Type A to begin a game. During certain portions of the game, other blue doors similar to this can be found. Enter them and finsh the Target practices by fetting 3000 points or higher to get 6 bottle caps. After you get 6, talk to the merchant and end the game. If you collected 6 different caps of the same game type, you will get some pesetas. |
| Action | Result |
| Score 3000 or more on Game Type A | Leon with Rocket Launcher |
| Score 3000 or more on Game Type A | Leon with Handgun |
| Score 3000 or more on Game Type A | Leon with Shotgun |
| 3000 or more points in Game D. | Maria |
| Score 3000 or more on Game Type C | Merchant |
| Score 3000 or more on Game Type A | Luis Sera |
| Score 3000 or more on Game Type C | Leader Zealot |
| 3000 or more points in Game D. | Isabel |
| 4000 or more points in Game D. Hit all targest in Game D except Ashley. | J.J. |
| Score 3000 or more on Game Type B | Dr. Salvador |
| Score 4000 or more on Game Type C. Alternately, hit all of the targets on Game Type C | Don Pedro |
| Score 3000 or more on Game Type B | Don Manuel |
| Score 3000 or more on Game Type B | Don Jose |
| Score 3000 or more on Game Type B | Don Esteban |
| Score 3000 or more on Game Type B | Don Diego |
| Score 4000 or more on Game Type B. Alternately, hit all of the targets on Game Type B | Bella Sisters |
| Score 3000 or more on Game Type A | Ashley Graham |
| Score 4000 or more on Game Type A. Alternately, hit all of the targets on Game Type A | Ada Wong |
| 3000 or more points in Game D. | Soldier w/ dynamite,Soldier w/ hammer,Soldier w/ stun-rod |
| Score 3000 or more on Game Type C | Zealot with Bowgun,Zealot with Scythe,Zealot with Shield |
| Mercenaries Mode Onlockables |
| Beat each level of Merceneraies with a specific amount of Stars in order to unlock special features. |
| Action | Result |
| Get five stars on all levels with all the characters | Handcannon (in main game) |
| Beat the Waterworld with a four star rank | Albert Wesker |
| Beat the Castle with a four star rank | Jack Krauser |
| Beat the Commando Base with a four star rank | Hunk |
| Beat the Pueblo level with a four star rank | Ada |
| Ada's Report |
| Completing each chapter in Separate Ways unlocks a part of Ada's report in Extras. Complete all 5 chapters to get the full report. |
| Action | Result |
| Complete Chapter 1 in Separate Ways | Ada's report on Los Illuminados |
| Complete Chapter 2 in Separate Ways | Ada's report on Luis Sera |
| Complete Chapter 3 in Separate Ways | Ada's report on Jack Krauser |
| Complete Chapter 4 in Separate Ways | Ada's report on Leon Scott Kennedy |
| Complete Chapter 5 in Separate Ways | Ada's report on Albert Wesker |
| Hat trick and strike a pose |
| This can only be done if Leon is wearing the "mafia" outfit and has the Chicago Typewriter equiped. Hold R1 to take aim and then press square. Doing so will cause Leon to remove his hat, adjust it, and then place it back on his head. Continue to do this. On the 4th time Leon will remove the hat, toss it in the air, catch it, and then stike a pose. |
| Heavy Ashley |
| When you unlock the knight costume for Ashley, not only will she be too heavy to be hurt and picked up by ganados, but will even give Leon the pains. Whenever you need to catch her after jumping down, Leon will go down on a knee while catching the heavy Ashley, then hold his back in pain. |
| Perverted Leon |
| When you climb up a ladder with ashley, wait until she comes up and then jump back down. You will then need to catch Ashley, instead of doing that, aim your crosshair until ashley's skirt and she'll cover it up and then she'll call you a pervert. |