Metal Gear Solid 4: Guns of the Patriots (PlayStation 3)

Pros: Perfectly refined/innovative/varied gameplay
Gorgeous art direction--not as technically powerful as Uncharted 2, but the character designs are unparalleled
Cinematic Cutscenes--Awesome camera, great lip syncing
Epic Story
Perfect controls

Cons: Load times--as bad as the first Mass Effect.
The humor is an aquired taste
Can be corny at times if you're not a fan of Japanese style of dialogue, but much better than Final Fantasy and actually fairly realistic for a Japanese game

Summary: This is the most innovative Metal Gear game, which is ironic considering the series goes back twenty years. It is also, imo, the best. It's not for everybody, but for those who enjoy epic, cinematic stories, stealth gameplay, and deep characters, there is nothing closer to perfection than MGS4. I've never played a game that earns it's price of admission more than MGS4, and I've never been sadder to see a character go than Solid Snake. Farewell, old soldier, we hope the world can survive without you.